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Index > Protein center > MYB(Gene name) > Human
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  • MYB (Gene name),
  • Transcriptional activator Myb (Protein name ),  MYB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    MYB;
    Protein name:
    Transcriptional activator Myb;
    Alternative:
    Proto-oncogene c-Myb;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds MYBBP1A. Interacts with HIPK2, MAF and NLK (By similarity). Binds to HIPK1.
    Function:
    Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    640
    Sequence:
    50:
    MARRPRHSIY | SSDEDDEDFE | MCDHDYDGLL | PKSGKRHLGK | TRWTREEDEK | 
    100:
    LKKLVEQNGT | DDWKVIANYL | PNRTDVQCQH | RWQKVLNPEL | IKGPWTKEED | 
    150:
    QRVIELVQKY | GPKRWSVIAK | HLKGRIGKQC | RERWHNHLNP | EVKKTSWTEE | 
    200:
    EDRIIYQAHK | RLGNRWAEIA | KLLPGRTDNA | IKNHWNSTMR | RKVEQEGYLQ | 
    250:
    ESSKASQPAV | ATSFQKNSHL | MGFAQAPPTA | QLPATGQPTV | NNDYSYYHIS | 
    300:
    EAQNVSSHVP | YPVALHVNIV | NVPQPAAAAI | QRHYNDEDPE | KEKRIKELEL | 
    350:
    LLMSTENELK | GQQVLPTQNH | TCSYPGWHST | TIADHTRPHG | DSAPVSCLGE | 
    400:
    HHSTPSLPAD | PGSLPEESAS | PARCMIVHQG | TILDNVKNLL | EFAETLQFID | 
    450:
    SFLNTSSNHE | NSDLEMPSLT | STPLIGHKLT | VTTPFHRDQT | VKTQKENTVF | 
    500:
    RTPAIKRSIL | ESSPRTPTPF | KHALAAQEIK | YGPLKMLPQT | PSHLVEDLQD | 
    550:
    VIKQESDESG | IVAEFQENGP | PLLKKIKQEV | ESPTDKSGNF | FCSHHWEGDS | 
    600:
    LNTQLFTQTS | PVADAPNILT | SSVLMAPASE | DEDNVLKAFT | VPKNRSLASP | 
    640:
    LQPCSSTWEP | ASCGKMEEQM | TSSSQARKYV | NAFSARTLVM | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    SMR:
    KEGG:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Transcriptional activator Myb
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    E1055m
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    ELISA Kit for Human Transcriptional activator Myb
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    E1055h
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    ELISA Kit for Human Transcriptional activator Myb
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    E1055b
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    96T
    ELISA Kit for Human Transcriptional activator Myb
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    E1055c
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    96T
    CLIA Kit for Human Transcriptional activator Myb
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    U1055c
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    96T
    CLIA Kit for Human Transcriptional activator Myb
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    U1055h
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    MSDS:
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    96T
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    CLIA Kit for Human Transcriptional activator Myb
    Cat.:
    U1055b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Transcriptional activator Myb
    Cat.:
    U1055m
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    Packing:
    96T
    Polyclonal Antibody for Human Transcriptional activator Myb
    Cat.:
    P1055Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Transcriptional activator Myb
    Polyclonal Antibody for Human Transcriptional activator Myb
    Polyclonal Antibody for Human Transcriptional activator Myb
    Cat.:
    P1055Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Transcriptional activator Myb
    Monoclonal Antibody for Human Transcriptional activator Myb
    Monoclonal Antibody for Human Transcriptional activator Myb
    Monoclonal Antibody for Human Transcriptional activator Myb
    Protein for Human Transcriptional activator Myb
    Protein for Human Transcriptional activator Myb
    Protein for Human Transcriptional activator Myb
    Protein for Human Transcriptional activator Myb

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    Linearity
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    References
    1. 1.
      "Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus."
      Majello B. , Kenyon L.C. , Dalla-Favera R.
      Proc. Natl. Acad. Sci. U.S.A.83:9636-9640(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Alternative splicing of the human c-myb gene."
      Westin E.H. , Gorse K.M. , Clarke M.F.
      Oncogene5:1117-1124(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    3. 3.
      "Genome annotation of a 1.5 Mb region of human chromosome 6q23 encompassing a quantitative trait locus for fetal hemoglobin expression in adults."
      Close J.P. , Game L. , Clark B. , Bergounioux J. , Gerovassili A. , Thein S.L.
      BMC Genomics5:33-33(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4)
    4. 4.
      "Characterization of the complete sequence structure of the human c-myb gene."
      Westin E.H. , Gorse K.M.
      Submitted (1995-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 3; 4; 5 AND 6)
      tissue: Liver.
      tissue: Placenta.
    5. 5.
      Gaillard C. , Perbal B.
      Submitted (1998-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    6. 6.
      "Complex RNA splicing produces multiple forms of c-Myb with distinct transcriptional activities."
      O'Rourke J.P. Jr. , Ness S.A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 7; 8; 9; 10 AND 11);ALTERNATIVE SPLICING
    7. 7.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Testis.
    10. 10.
      "Identification of a second promoter in the human c-myb proto-oncogene."
      Jacobs S.M. , Gorse K.M. , Westin E.H.
      Oncogene9:227-235(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-47 (ISOFORM 1)
    11. 11.
      "Positive autoregulation of c-myb expression via Myb binding sites in the 5' flanking region of the human c-myb gene."
      Nicolaides N.C. , Gualdi R. , Casadevall C. , Manzella L. , Calabretta B.
      Mol. Cell. Biol.11:6166-6176(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-7
    12. 12.
      "Studies of the human c-myb gene and its product in human acute leukemias."
      Slamon D.J. , Boone T.C. , Murdock D.C. , Keith D.E. , Press M.F. , Larson R.A. , Souza L.M.
      Science233:347-351(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 47-640 (ISOFORMS 1 AND 12)
    13. 13.
      "Identification of alternatively spliced transcripts for human c-myb: molecular cloning and sequence analysis of human c-myb exon 9A sequences."
      Dasgupta P. , Reddy E.P.
      Oncogene4:1419-1423(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
    14. 14.
      "Transcriptional activation by human c-myb and v-myb genes."
      Kalkbrenner F. , Guehmann S. , Moelling K.
      Oncogene5:657-661(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN
    15. 15.
      "p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3."
      Tanikawa J. , Ichikawa-Iwata E. , Kanei-Ishii C. , Nakai A. , Matsuzawa S. , Reed J.C. , Ishii S.
      J. Biol. Chem.275:15578-15585(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIAH1;DEGRADATION
    16. 16.
      "HIPK1 interacts with c-Myb and modulates its activity through phosphorylation."
      Matre V. , Nordgaard O. , Alm-Kristiansen A.H. , Ledsaak M. , Gabrielsen O.S.
      Biochem. Biophys. Res. Commun.388:150-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY HIPK1;INTERACTION WITH HIPK1;SUBCELLULAR LOCATION
    17. 17.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-471 AND LYS-480;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "BCL6 positively regulates AID and germinal center gene expression via repression of miR-155."
      Basso K. , Schneider C. , Shen Q. , Holmes A.B. , Setty M. , Leslie C. , Dalla-Favera R.
      J. Exp. Med.209:2455-2465(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
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